JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2013, Vol. 51 ›› Issue (11): 56-60.

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Structural determination of riccardin D′s metabolites in rats

LING Xiao1,2, GUO Dong-xiao2, LOU Hong-xiang1   

  1. 1. Department of Natural Product Chemistry, School of Pharmaceutical Sciences,
    Shandong University, Jinan 250012, China;
    2. Institute for Food and Drug Control of Shandong Province, Jinan 250101, China
  • Received:2013-06-28 Online:2013-11-10 Published:2013-11-10

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Abstract:

Objective  To investigate the metabolism pathway and identify the metabolites of riccardin D in vivo after oral administration in rats. Methods  Using HPLC, the metabolites were purified from rats′ bile samples after oral administration of riccardin D 40mg/kg in rats. The structures of the metabolites were identified by HPLC-MS/MS and confirmed by NMR. Results  The riccardin D′s metabolites were the conjugates with glucuronate and were identified as a mixture of two atropisomers. Conclusion  The riccardin D′s main metabolism pathway in vivo is phase Ⅱ metabolism and the metabolites are the conjugate with glucuronate.

Key words: Riccardin D; Metabolite; Rats

CLC Number: 

  • R574
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