Abstract:

Objective   To observe the clinical efficacy and safety on intravesical instillation of sodium hyaluronate for treatment of non-bacterial cystitis. Methods   Totally 28 patients with non-bacterial cystitis were included. They received intravesical instillation(sodium hyaluronate solution of 50ml/40mg) once a week for 4 weeks, then once every two weeks for the next 4 weeks and at last once a month for the next 2 months. The follow-up visited was performed once every two weeks, ended at the 16th week. Evaluate the efficacy and safety of the sodium hyaluronate according to patients’ symptom assessment scores(VAS, LUTS) and the micturition diary. Results   28 patients all completed the instillation and follow-up. At the 16th week, the VAS score dropped from 6.86±1.74 to 2.71±0.90(P<0.001), the LUTS score dropped from 41.07±11.96 to 23.25±6.07(P<0.001) and the mean BC(bladder capacity) rose from (106.71±22.65)mL to (163.93±32.00)mL(P<0.001). Conclusion   The short-term curative effect and safety of intravesical instillation of sodium hyaluronate to treat the non-bacterial cystitis is worth affirmation. It can significantly relieve symptoms in order to improve the quality of life.

Key words: Hyaluronic acid； Nonbacterial cystitis； Instillation； Efficacy