JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (11): 77-80.doi: 10.6040/j.issn.1671-7554.0.2014.281

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Effect of LMWH on severe preeclampsia complicated with FGR and HO-1 expression

DUAN Yan, LIU Yuanyuan   

  1. Department of Obstetrics and Gynecology, Shengli Oil Central Hospital, Dongying 257034, Shandong, China
  • Received:2014-05-04 Published:2014-11-10

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Abstract: Objective To investigate the effect of low molecular weight heparin (LMWH) on severe preeclampsia complicated with fetal growth restriction (FGR) and expression of hemeoxygenase-1(HO-1). Methods A total of 97 cases were randomized into LMWH group (n=44) and control group (n=53). After 7-day treatment, changes of placental weight were observed. Villous stromal cells, fibrinoid effusion and necrosis, decrease, obstruction and infarction of villus blood vessels were observed with HE staining. HO-1 expression was detected with immunohistochemical method. Results The placental weight increased significantly in LMWH group (P<0.05). Hypoxic-ischemia changes of placenta decreased markedly in LMWH group (P<0.05). The HO-1 protein expression increased remarkably in LMWH group (P<0.05). Conclusion LMWH can improve villi morphology and ischemia hypoxia of placenta for severe preeclampsia complicated with FGR. Additionally, it can increase the expression of HO-1, dilate vessels, and protect the placenta from being oxidized, thus promoting the fetal growth.

Key words: Severe preeclampsia, Placental pathology, Fetal growth restriction, Low molecular weight heparin, Hemeoxygenase-1, Placenta weight

CLC Number: 

  • R714.24
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