JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2012, Vol. 50 ›› Issue (3): 83-86.

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Therapy and effect of GnHRa on sex hormone and bone mineral
density in patients with endometriosis

CHENG Kai-hua1, ZHANG Li-xin2   

  1. 1.Department of Gynecology, Southeast University Hospital, Nanjing 210018, China;
     2. Department of Gynecology and Obstetrics, Nanjing BenQ Hospital, Nanjing 210017, China
  • Received:2011-11-29 Online:2012-03-10 Published:2012-03-10

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Abstract:

Objective   To investigate the change of sex hormone and bone mineral density (BMD) in patients with endometriosis (EM) using the gonadotropin-releasing hormone agonist (GnHRa). Methods   60 patients with EM were divided into group A (n=30) and group B (n=30)， and 30 healthy female patients were selected as group C. Group A received leuprorelin acetate, group B received leuprorelin acetate combined with 7-tibolone, while group C received nothing. The clinical efficiency, levels of FSH, LH, E2 and P and BMD were observed.  Results   There was no significant difference in clinical efficiency between group A and group B. The levels of FSH, LH, E2 and P after 4 weeks and 12 weeks in groups A and B more significantly decreased than those before treatment and in group C. The levels of E2 and P in group B were higher than those in group A after 4 weeks and 12 weeks. The levels of BMD in groups A and B did not significantly decrease. Conclusion   GnHRa can decrease the levels of FSH, LH, E2 and P，and GnHRa combined with the add-back therapy can release the decreasing extent of sex hormone and reduce the bone loss.

Key words: Gonadotropin-releasing hormone agonist; Endometriosis; Estrogen; Bone mineral density

CLC Number: 

  • R711.71
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