Abstract:

Objective   To explore the relationship between the concentrations of type Ⅲ procollagen(PCⅢ) and aminoterminal propeptide of type Ⅲ procollagen(PⅢNP)in serum of obstructive nephropathy and the damage and recovery of renal function. Methods   Thirty patients suffering from unilateral hydronephrosis were divided into three groups: the mild hydronephrosis group(10 cases) and the moderate hydronephrosis group (10 cases) and severe hydronephrosis group (10 cases) . 10 healthy people were chosen as the control group. PCⅢ and PⅢNP concentrations in serum were measured by radioimmunoassay (RIA). Preoperative and postoperative Glomerular Filtration Rates (GFRs)were measured by nephrodynamic imaging and then the relationship between PCⅢ and PⅢNP concentrations in serum and GFRs was studied. Results   ①PCⅢ and PⅢNP concentrations in serum of the three hydronephrosis groups were all higher than the control group, and PCⅢ and PⅢNP concentrations in serum increased gradually with the increasing degree of the hydronephrosis. The differences between the hydronephrosis group and the control group and among the hydronephrosis groups were significant(P<0.05).②There was a negative correlation between PCⅢ and PⅢNP concentrations in serum of the three hydronephrosis groups and preoperative GFRs(r=-0.819，P<0.01).③The postoperative GFRs were higher than the preoperative GFRs of the mild and moderate hydronephrosis groups(P<0.05) and the postoperative GFRs of the severe hydronephrosis group did not significantly recover(P>0.05). Conclusion   PCⅢ and PⅢNP concentrations in serum of the hydronephrosis groups gradually increased with the increasing degree of the hydronephrosis. There was a negative correlation between PCⅢ and PⅢNP concentrations in serum of the three hydronephrosis groups and preoperative GFRs. So we presumed that the PCⅢ and PⅢNP concentrations in serum could be used to indicate the changes of renal function in hydronephrosis, on condition that the possibility of other organs′ fibrosis was ruled out.

Key words: Hydronephrosis; Renal fibrosis; Collagen type Ⅲ; Glomerular filtration rate