JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2012, Vol. 50 ›› Issue (3): 24-28.

• Articles • Previous Articles     Next Articles

GFR and DEC1 protein co-expression promotes lymph node
metastasis in lung adenocarcinoma

MA Yu-hua1,2, ZHENG Yan3, JIA Yan-fei3, WANG Yun-shan3   

  1. 1. School of Medicine,Shandong University, Jinan 250012, China;
     2. Department of Clinical Laboratory Medicine, Linyi People′s Hospital, Linyi 276003, Shandong, China;
    3. Central Laboratory, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, China
  • Received:2011-12-25 Online:2012-03-10 Published:2012-03-10

PDF (PC)

422

Abstract:

Objective   To investigate the association of expressions of epidermal growth factor receptor(EGFR ) and differentiated embryochondrocyte expressed gene 1 (DEC1) in lung adenocarcinoma to its clinicopathological characteristics. Methods   Expressions of EGFR and DEC1 in 75 cases of lung adenocarcinoma were detected by immnohistochemistry. Results   The positive membrane expression rates of EGFR and nuclear DEC1 in lung adenocarcinoma tissues were 45.3%（34/75）and 54.7%（41/75）respectively, which were significantly higher than those in adjacent normal tissues (P＜0.001). Expression of membrane EGFR in lung adenocarcinoma was related to tissue histological differentiation (P=0.033), lymph node metastasis(P=0.006) and distant metastasis(P=0.043). Expression of nuclear DEC1 in lung adenocarcinoma was associated with patients′ age(P=0.026) and tumor size（P=0.047）. Co-expression of EGFR and DEC1 in lung adenocarcinoma was related to lymph node metastasis（P=0.024）. Conclusion   The interaction of EGFR and DEC1 promotes lymph node metastasis in lung adenocarcinoma.

Key words: Lung adenocarcinoma; Epidermal growth factor receptor;  Differentiated embryo-chondrocyte expressed gene 1; Lymph node metastasis

CLC Number: 

  • R734.2
[1] XU Xiao-ya, BI Yu-li, JIANG Man, XU Ji-ying, ZHANG Peng-fei, HAN Ming-yong. Vascular endothelial growth factor (VEGF) promotes lung carcinoma metastasis via VEGFR1 in mouse model [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(11): 25-29.
[2] . [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(11): 108-110.
[3] TIAN Tian-tian1, LI Ji-sheng1, WANG Ya-wei1, MA Dao-xin2, WANG Xiu-wen1. Genistein exerts antitumor effects in small cell lung cancer H446 cells via suppressing the activity of FoxM1 pathway [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(06): 44-48.
[4] LIU Bing1， YU Zhuang1， HOU Xian-peng1， YAO Ru-yong2. Different expressions of EGFR and HER-3 genes in human lung adenocarcinoma cells and pemetrexed-resistant cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(5): 20-23.
[5] ALIMUJIANG·Stiwaerdi, ZHANG Tao, PATIGULI·Aerxiding, LIU Li. Clinical analysis of recombinant human endostatin combined with gemcitabine and  cisplatin therapy in advanced non-small cell lung cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(3): 95-98.
[6] DONG Xue-li, MU Xiao-yan, LIU Qing-liang, SUN Jie. Effects of erlotinib combined with celecoxib on growth and angiogenesis of human lung cancer xenograft model [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(2): 49-52.
[7] . [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(10): 130-131.
[8] LIU Qing-liang1, MU Xiao-yan1, WANG-Jing2, CHI Xiang-yu2, ZHANG Min3, MA Wei-xia3. Inhibitory effects of RNA interference and Erlotinib by blocking epidermal
growth factor receptor pathway on the proliferation of A549 cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(9): 11-.
[9] FAN Heng-jian, ZHANG Yu-ke, XIAO Wei, ZHANG Yi, LI Hai-jun, WANG De-xiang. Changes of Treg and Th17 cells in the peripheral bloods of patients with
lung adenocarcinoma and their prognostic significance [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(9): 73-78.
[10] WANG Ji-xia, LI Gui-xin, HUANG Yan, WANG Li-juan. Expressions and clinical significances of E1AF，MMP-7 and uPA in nonsmall cell lung cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(7): 109-.
[11] XU Tong-zhen, SUN Xue-fei, REN Dong-mei, YANG Guo-tao. Antiproliferation activity of luteolin and its role in combined chemotherapy on lung cancer A549 cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(7): 50-54.
[12] LIU Hai-rong1， YU Jin-ming2， LI Yan1， LIANG Jing1， LIU Xiao-lin1. Study of the relationship between ER， PR， C-erB-2 and
bone metastasis of  lung adenocacinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(4): 91-.
[13] SUN Xue-fei, PEI Yan-tao,YIN Qiu-wei, YANG Guo-tao, WANG De-jiang. Inhibitory effect of Radix Actinidiae extractive on transplantation
tumor of the lung cancer cell line A549 in nude mice [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(2): 38-42.
[14] LI Peng, LIU Qi， HAN Ming-yong. PET/CT，CEA and CYFRA21-1 predicting the therapeutic effect of targeted drug on non-small cell lung cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(1): 129-132.
[15] JIANG Xiao-dong1,2, DAI Peng2, WU Jin2, SONG Da-an2, YU Jin-ming3. Weekly recombinant human endostatin as a hypoxic tumor cell radio sensitizer combined with radiotherapy for non-small-cell lung cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(11): 108-.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd