JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2012, Vol. 50 ›› Issue (3): 96-.

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A preliminary study toward validating EGFR expression in esophageal
carcinoma as used to predict the sensitivity to chemoradiotherapy

LI Qiang， YANG Zhe， ZHAO Ying， HAN Jun-qing   

  1. Center for Oncology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
  • Received:2011-09-28 Online:2012-03-10 Published:2012-03-10

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Abstract:

Objective   To study the usefulness of EGFR expression as applied to predict the sensitivity to chemoradiotherapy in esophageal carcinoma. Method   Tissue samples were collected from 35 esophageal cancer patients before any treatment was done. Immunohistochemistry was performed for EGFR. Chemoradiotherapy was carried about on all patients, and the sensitivity was reviewed against the immunohistochemical staining patterns. Result   The complete response rate (CR) in the EGFR-positive group and EGFR-negative group was 57.7%（15/26）and 11.1%（1/9）, respectively, showing a significant difference(P=0.022). Conclusion   This observation suggests that EGFR expression level (YES vs NO) may help predict the sensitivity to chemoradiotherapy for esophageal carcinoma.

Key words: Esophageal  neoplasms； Concurrent chemoradiation； Epidermal growth factor receptor； Sensitivity

CLC Number: 

  • R735.1
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