Abstract:

Objective   To synthetically evaluate the risk factors related to cervical cancer of Chinese women. Methods   Published studies concerning risk factors and cervical cancer about Chinese women were searched systemically and assessed by NOS (Newcastle-Ottawa Scale) items from January 1990 to June 2011. 16 studies involving 11,126 women were selected for Meta-analysis. Stata10.0 software was used for data analysis and for calculating OR and its 95% CI of every risk factor.  Results   According to NOS items, 6 studies were classified as degree A and 10 studies were evaluated as level B. Among the 16 analyzed factors, 12 factors had statistical significances. Gestationrelated factors were as follows: gravidity≥3, OR=2.384(95% CI:1.659-3.425); parity≥3, OR=2.265(95% CI:1.669-3.074); number of abortions≥3, OR=3.713(95% CI:2.4705.581); and age at first pregnancy≤21 years, OR=2.390(95% CI:1.731-3.225).  Sexual behavior-related factors were as follows: marriage times≥2, OR=2.522(95% CI: 1.7143.713); age at first sex≤20 years, OR=3.467(95% CI: 2.4564.893); number of sexual partners≥3, OR=2.539(95% CI:1.613-3.996). Gynaecological diseaserelated factors involved: a history of sexually transmitted diseases(STDs), OR=5.861(95% CI:1.048-13.67); when with a history of gynecological diseases, OR=4.807(95% CI:2.899-7.971); education years≤9 years, OR=3.536(95% CI: 2.204-5.672); active and passive smoking, OR=3.055(95% CI:2.435-3.833); resident places, OR=2.134(95% CI: 1.010-4.509).  Conclusion   Many factors are closely related to cervical cancer in fertile women in China.

Key words: Uterocervical neoplasms; Risk factors; Meta-analysis