Abstract:

Objective   To investigate various correlation factors associated with post-stroke depression (PSD), and provide a basis for early diagnosis and intervention of PSD. Methods   A case-control study was used. Eligible hospitalized stroke patients with first-ever lacunar infarction from January 2010 to April 2011 were divided into the depression group and the control group. Multivariate unconditional logistic regression analysis was made after single variable analysis. Results   138 patients were surveyed, among whom 123 completed all the investigations. The overall incidence of PSD was 35%（43 cases）. The following four factors were associated with PSD, severity of neurological deficits, number of lacunar infarcts and basal ganglia lesions as risk factors, and level of education as the protective factor. Conclusion   The severity of neurological impairment is the most important risk factor for PSD, whereas, good education is the protective factor.

Key words: Depression, cerebrovascular accident; Lacunar infarction; Risk factors; Logistic models