Abstract:

Objective   To investigate the relationship between plasma omentin-1, interleukin-18 (IL-18) levels and the pathogenesis of coronary disease through detecting plasma omentin-1 and IL-18 levels of patients with coronary disease and patients in the control group. Methods   74 patients (without diabetes mellitus) hospitalized from May 2011 to November 2011 were divided into two groups 54 cases in the coronary disease group(32 cases in the unstable angina pectoris group, 22 cases in the stable angina pectoris group), and 20 cases in the control group. Venous blood samples were collected from the patients after an overnight fast the next day after admission to hospital. The plasma omentin-1 and IL-18 levels were detected by enzyme-linked immunosorbent assay( ELISA), and the height, body mass, blood pressure, fasting blood sugar, total cholestero1, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol and other indicators were measured． Results   The plasma omentin1 level in the coronary disease group was lower than that in the control group, and the difference between the two groups was statistically significant(P＜0.01). The plasma IL18 level in the coronary disease group was higher than that in the control group, and the difference between the two groups was statistically significant (P＜0.05). Conclusion   The plasma omentin-1 levels decrease and IL-18 levels increase in patients with coronary disease, which may play a role in the pathogenesis of the coronary disease.

Key words: Omentin-1; Interleukin-18; Coronary disease; Unstable angina pectoris; Stable angina pectoris