JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2012, Vol. 50 ›› Issue (6): 80-.

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Meta-analysis of temozolomide for highgrade gliomas

WANG Yao-wu1, YIN Chun-li1, ZHANG Zhi-yong1, ZHANG Hong-yi1,
ZHANG Kun1, ZHANG Zhi-min2, LIAO Heng1   

  1. 1. Department of Neurosurgery, Tangshan Gongren Hospital, Tangshan 063000, Hebei, China;
    2. Department of Neurosurgery, Shijiazhuan yiling Hospital, Shijiazhang 050000, Hebei, China
  • Received:2012-03-16 Online:2012-06-10 Published:2012-06-10

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Abstract:

Objective   To compare and evaluate the effects of temozolomide and other drugs in the high-grade gliomas post-surgical treatment. Methods   In this literature review study, papers on temozolomide for high-grade gliomas were collected and Meta-analysis was performed using Stata software. Results   7 papers were included. Of 438 patients, 227 were in the treatment group and 211 were in the control group. The Meta analysis results showed that M-H pooled OR was 3.70 and 95% CI was 2.37-5.79, while the Mantel-Haenszel test showed that Z was 5.75 and P<0.01, which indicated the effects of temozolomide was significantly better than other drugs. Conclusion   At present, temozolomide can be used as the drug of choice  for high-grade gliomas.

Key words: High-grade gliomas; Temozolomide; Meta analysis

CLC Number: 

  • R739.4
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