JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2012, Vol. 50 ›› Issue (6): 42-.

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Comparison of mechanical properties between glutaraldehyde tanned
donkey pericardium and bovine pericardium in vitro

CHEN Shan-liang1, XU Li2, WANG Xue-mei2, LIU Yu-xi3,
LI Quan2, ZHANG Hui2, LU Ping2, LIU Tian-qi2   

  1. 1. Weifang Medical College, Weifang 261053, Shandong, China;
    2. Department of Cardiac Surgery, Shandong Provincial Qianfoshan Hospital Affiliated to Shandong University,
    Shandong Heart Transplantation and Materials Engineering Technology Research Center, Jinan 250014, China;
    3. The Basic Medical Sciences of Shandong University of Traditional Chinese Medicine, Jinan 250355, China
  • Received:2012-01-21 Online:2012-06-10 Published:2012-06-10

Abstract:

Objective   To investigate donkey pericardial mechanical properties in  biological valve preparation conditions. Methods   Glutaraldehyde tanned acellular donkey pericardium was regarded as the experimental group, and glutaraldehyde tanned acellular bovine pericardium was regarded as the control group. The donkey pericardium and bovine pericardium were observed under a light microscope to identify the decellularized effect. The properties of temperature shrinkage, pericardial thickness, maximum load, tensile strength and tear strength were compared between the two groups. Results   There were no residual nuclei in the decellularized donkey and bovine pericardium. There were many visible diffuse nuclei existing in the non-decellularized donkey and bovine pericardium. There was no difference between the two groups. The statistical analysis of shrinking temperature showed no significant difference between the experimental group (87.5000±0.5916)℃ and the control group(87.5600±0.3715)℃ (P>0.05 ).  The donkey pericardium were significantly thinner in thickness and higher in tensile strength than the bovine pericardium (P<0.001). However, there were no differences between the two groups in temperature shrinkage, maximum load and tear strength (P>0.05). Conclusion   Glutaraldehyde tanned donkey pericardium is suitable for the production of heart valve materials with mechanical properties.

Key words: Glutaraldehyde; Biological valve; Bovine pericardium; Donkey pericardium

CLC Number: 

  • R318.08
[1] WANG Jian-guang1, LIU Tian-qi2,WANG Xue-mei2, XU Li2, LIU Yu-xi3, WANG Dong2,LI Quan2 . Comparison of genipin- and glutaraldehyde-tanned bovine pericardia [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(5): 24-28.
[2] ZHANG Shi-jie1,CHEN Fei1,JIANG XIN-quan2. Cell compatibility of a new type polyporous RGD-PLGA/HA scaffold in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(5): 29-33.
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