Abstract:

Objective    To investigate the diagnostic value of survivin determination in pulmonary cancerous pleural effusion. Methods     The pleural fluid specimens were collected from 102 patients with lung cancer and 87 patients with tuberculous pleurisy. Survivn was determined by ELISA. And the levels of CEA, NSE, and CYFRA211 were detected in the pleural effusion. The results were analyzed with statistical methods.  Results    The survivn level of the malignant pleural effusion was 52.290±41.421pg/mL, which was significantly higher than that of the tuberculous pleural effusion (17.286±16.734pg/mL)（P<0.01）. Survivin is more sensitive in  detemines of pleural effusion than the above other three tumor makers (CEA,NSE, and CYFRA21-1). Conclusion     Survivin may be used as a new sensitive and significant marker for diagnosis of lung cancer. 

Key words: Survivin； Dleural effusion； Lung cancer； Diagnosis