JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Calcium dobesilate in the treatment of early diabetic nephropathy

DONG Jing1，LIANG Cui-ge2，ZHANG Xiao-qian3，LI Ming-long1，LIU Zhan-feng1，ZHAO Jia-jun1，YU Gui-na1   

  1. Department of Endocrine, 1. Provincial Hospital affiliated to Shandong University, Jinan 250021, China;2. Linyi People′s Hospital, Linyi 276003, Shandong, China; 3. Shandong Qianfoshan Hospital
  • Received:2007-08-24 Revised:1900-01-01 Online:2008-01-16 Published:2008-01-16
  • Contact: YU Gui-na

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Abstract: To investigate the clinical effects of calcium dobesilate on early diabetic nephropathy. Methods42 patients with early diabetic nephropathy were randomly divided into the treatment and control groups. All the patients were given treatment to control blood glucose and 21 patients in the treatment group were treated with calcium dobesilate (500?mg, three times per day) for 12 weeks. Urinary albumin excretion, plasma endothelin, serum nitric oxide, serum glucose, glycosylated heamoglobin A1c, hepatic and renal function were determined before and after the treatment. ResultsAfter 12 weeks of treatment, in the treatment group the levels of UAE were significantly decreased（P＜0.01), the levels of ET were decreased, the levels of NO were increased, and the levels of serum glucose and HbA1c had no changes. However, the levels of UAE, ET, NO, serum glucose and HbA1c had no changes in the control group. ConclusionCalcium dobesilate can decrease the levels of UAE in patients with early diabetic nephropathy and postpone the development of diabetic nephropathy, which may be due to its correction of abnormal renal hemodynamics through decreasing ET and increasing NO.

Key words: Diabetic nephropathy, Calcium dobesilate, Endothelin, Nitric oxide

CLC Number: 

  • R587.2
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