JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2010, Vol. 48 ›› Issue (7): 47-51.

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A new experimental model of traumatic retinal detachment in rabbit

MA Ting1，2, WANG Chang-guan1, MA Zhi-zhong1, XU Hang-xiu3, JIANG Cai-hui3   

  1. 1.Department of Ophthalmology, Peking University Third Hospital, Beijing 100083, China;
    2. Department of Ophthalmology, The No. 401 hospital of PLA, Qingdao 266071, Shandong, China;
    3. Department of Ophthalmology, The General Hospital of PLA, Beijing 100859, China
  • Received:2009-03-12 Online:2010-07-16 Published:2010-07-16

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Abstract:

Objective   To establish a new rabbit model of experimental traumatic retinal detachment caused by non-exogenous-inducer and to observe the corresponding histological changes in retina.   Methods   A scleral incision was made 2 mm posterior and parallel to the limbus at the posterior and superior quadrant of the rabbit eye. The vitreous was squeezed out. BSS was injected into the sub-retinal space to produce a 180° retinal detachment. 8-0 absorbable suture was used for the wound. Pathological changes were observed under histopathological light microscope and electron microscope. Results   Neural retina degeneration of various degrees was observed in all the layers of the retina after the retinal detachment, with the most significant damages found in the photoreceptors. Decreased cellular components and damaged structure were observed in the neurons. Changes such as hyperplasia, hypertrophy and gliosis were found in the Müller cells.  Conclusions   This new animal model has the advantage of high incidence of retinal detachment and ideal development of proliferative vitreoretinopathy in later stage, thus can be used for the researches on retinal detachment and proliferative vitreoretinopathy.

Key words: Retinal detachment; Traumatic; Animal model

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