Abstract:

To determine the serum level of soluble B7H4 in gastric cancer and to explore its clinical significance. MethodUsing the ELISA sandwich method, the serum level of soluble B7H4 was determined in 61 cases of gastric cancer and 51 cases of normal controls, then correlations between soluble B7H4 and pathological types, before and after surgical treatment and other serum markers of gastric cancers were analyzed. ResultsThe serum level of soluble B7H4 in gastric cancer ［（49.14±16.16）μg/L］was significantly higher than that in normal people［（32.67±12.28）μg/L］, and there was a significant difference (P＜0.01). The serum level of soluble B7H4 in poorly differentiated adenocarcinoma ［(64.51±20.67)μg/L］was higher than that in well differentiated adenocarcinoma［（36.78±13.39）μg/L］, mucinous adenocarcinoma［(42.79±12.31)μg/L］ , and signetring cell carcinoma［（44.62±12.27）μg/L］, and there were significant differences among them (P＜0.05). The serum level of soluble B7H4 in gastric cancer before surgical treatment［（58.09±15.28）μg/L］was higher than that in gastric cancer after surgical treatment［（38.58±9.49）μg/L］(P＜0.01). The serum level of sB7H4 in gastric cancer was positivelycorrelated with serum levels of CEA and CA199（P＜0.01）. ConclusionA high level of serum soluble B7H4 in gastric cancer has a positive relationship to pathological types, surgical treatment and other serum markers of gastric cancers, which reveals that soluble B7H4 plays an important role in cancer generation and development.

Key words:  Gastric neoplasms； B7H4； ELISA； Sandwich methodB7