Abstract:

To investigate mRNA and protein expressions of a killer cell immunoglobulinlike receptor(KIR) 2DL1 in deciduas of unexplained first trimester spontaneous abortion. MethodsExpressions of KIR2DL1 mRNA and protein in deciduas of unexplained first trimester spontaneous abortion and normal first trimester pregnant women were determined by SYBR Green I realtime quantitative retroverse polymerase chain reaction (RTPCR) and Western blotting methods. Results① Expression of the KIR2DL1 mRNA in deciduas of the abortion group was less frequently than that of the control group (90.00% vs 96.67%,  P＞0.05); Expressive quantity of the KIR2DL1 mRNA was lower in deciduas of the abortion group compared with that of the control group(P＞0.05). ② Expression of the KIR2DL1 protein in deciduas of the abortion group was less frequent than that of the control group (86.67% vs 93.33%, P＞0.05). Expressive quantity of the KIR2DL1 protein in deciduas of the abortion group was significantly lower than that of the control group(P＜0.05). ConclusionDepressed expression of KIR2DL1 may correlate with occurrence of unexplained first trimester spontaneous abortion.

Key words: Killer cell immunoglobulinlike receptor; Decidua; Spontaneous abortion， recurrent