JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2009, Vol. 47 ›› Issue (9): 21-24.

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Mucociliotoxicity of theophylline/chitosan/βcyclodextrin 
microspheres as a sustained pulmonary delivery

ZHANG Xiaoqian1, ZHANG Jingjing2, ZHANG Weifen2   

  1. . Department of Medicine, Clinic Institute, Weifang Medical Univers ity, Weifang 261031, Shandong, China; 
    2. Department of Pharmacology, Elementary Institute, Weifang Medical University, Weifang 261053, Shandong, China
  • Received:2009-01-19 Published:2009-09-16

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Abstract:

To explore mucociliotoxicity of theophylline/chitosan/βcyclodextrin microspheres as pulmonary sustained drug delivery carriers. MethodsAn acute cell toxicity experiment (LDH and protein in BALF) and a mucociliotoxicity experiment were carried out. ResultsCiliary movement time of MS B microspheres was 512.33 minutes and ciliary beat frequency was 96.0%. The total contents of protein and LDH in BALF of the pulmonary delivery group were not significantly different from those of the control group. ConclusionThese results indicated microspheres possessed better adaptability. 

Key words: Aminophylline; Chitin; Microspheres; Biocompability

CLC Number: 

  • R944
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