Abstract: Objective To explore the association and risk factors between body composition and metabolic associated fatty liver disease(MAFLD), and to provide a theoretical basis for early prevention, screening and intervention of MAFLD. Methods A total of 4,046 healthy physical examiners were selected from April 2021 to April 2022, and the subjects were divided into MAFLD group(n=1,347)and non-MAFLD group(n=2,699)according to the examination results. The differences of general information, body composition and laboratory indices between the two groups were compared. Binary Logistic regression model was used to analyze the independent risk factors for MAFLD. Results The prevalence of MAFLD was 33.29%(1,347/4,046). The prevalence of MAFLD was higher in patients with hypertension, alcohol drinking, older age, overweight and abdominal obesity, with statistical significance(P<0.05). The values of body mass index(BMI), percent body fat(PBF), waist-to-hip ratio(WHR), visceral fat area(VFA), arm circumference(AC), weight, liver function, blood lipid, fasting blood glucose and blood pressure in the MAFLD group were significantly higher than those in the non-MAFLD group, with statistical significance(P<0.05). Binary Logistic regression analysis showed that VFA(OR=1.010, 95%CI:1.006-1.014, P<0.001), PBF(OR=1.239, 95%CI:1.091-1.408, P=0.001), WHR(OR=37.925, 95%CI: 2.866-501.899, P=0.006), AC(OR=1.387, 95%CI:1.327-1.449, P<0.001), TG(OR=2.049, 95%CI:1.841-2.279, P<0.001)were independent influencing factors of MAFLD. Conclusion PBF, WHR, VFA, and AC are recognized as independent determinants of MAFLD. Monitoring changes of body composition, reducing WHR, PBF and VFA, and actively controlling fasting blood lipid level are important in the prevention of MAFLD.

Key words: Body composition, Metabolic associated fatty liver disease, Percent body fat, Waist-to-hip ratio, Visceral fat area, Arm circumference