Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (4): 95-99.doi: 10.6040/j.issn.1671-7554.0.2019.1507

Previous Articles    

Correlation between cognitive ability and pulsatility index in patients with mild leukoaraiosis

GAO Chunyuan1, LIU Xingliang2, LOU Zhan2, LIU Zhankuang3, YUE Binghong2   

  1. 1. Basic Medical College, Hebei North University;
    2. Department of Neurology of First Affiliated Hospital, Hebei North University;
    3. Department of Geriatrics of First Affiliated Hospital, Hebei North University, Zhangjiakou 075000, Hebei, China
  • Published:2022-09-27

PDF (PC)

29

Abstract: Objective To investigate the correlation between cognitive ability and pulsatility index(PI)of middle celebral artery in patients with mild leukoaraiosis(LA). Methods A total of 46 patients with mild paraventricular LA treated during Apr. and Oct. 2019 who had the same education level were enrolled as study group, and another 50 volunteers without LA who had the same education level were selected as controls. The two groups were evaluated with Montreal Cognitive scale(MoCA), clock drawing test(CDT)and transcranial Doppler(TCD). The PI of each participant was recorded. Results The study group had significantly lower MoCA score(t=-3.780, P<0.001)but higher PI(t=6.875, P<0.001)than the control group. There was a negative correlation between MoCA score and PI in the LA patients(r=-0.852, P<0.05). In addition to declined overall cognitive level, the study group had lower scores of spatial and executive functions, attention and calculation, and delayed memory impairment than the control group(all P<0.05). There was a negative correlation between PI and spatial and executive functions(r=-0.800), attention and calculation(r=-0.386),and delayed memory impairment(r=-0.587). The study group had lower CDT score than the control group(t=-2.831, P<0.05), and the CDT score was negatively correlated with PI(r=-0.715, P<0.05). Conclusion Mild LA patients may have impaired cognitive function and cerebral flow reserve in the subclinical stage. In the early diagnosis of LA, PI is as important as MoCA. Comparison of impairment of different cognitive domains is helpful in the early intervention of LA, taking the correlation befween CDT and PI as an exemple.

Key words: Leukoaraiosis, Montreal Cognitive scale, Transcranial Doppler, Pulsatility index, Cerebral flow reserve

CLC Number: 

  • R743
[1] 陈燕梅, 李毅, 李海林, 等. 脑白质疏松对遗忘型轻度认知障碍患者认知功能和日常生活能力的影响[J]. 临床神经病学杂志,2017, 30(5): 330-332. CHEN Yanmei, LI Yi, LI Hailin, et al. Influence of leukoaraiosis on cognitive function and activities of daily life in patients with amnestic mild cognitive impairment[J]. Journal of Clinical Neurology, 2017, 30(5): 330-332.
[2] Aaslid R, Markwalder TM, Nornes H. Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries[J]. J Neurosurg, 1982, 57(6): 769-774.
[3] 陈阳, 于德华, 杨蓉, 等. 国内外认知功能障碍常用筛查量表及其社区应用[J]. 中国全科医学, 2018, 21(12): 1392-1396, 1401. CHEN Yang, YU Dehua, YANG Rong, et al. Community-based application of six common cognitive impairment screening tools at home and abroad[J]. Chinese General Practice, 2018, 21(12): 1392-1396, 1401.
[4] Aguilar-Navarro SG, Mimenza-Alvarado AJ, Palacios-García AA, et al. Validity and reliability of the Spanish version of the montreal cognitive assessment(MoCA)for the detection of cognitive impairment in Mexico[J]. Rev Colomb Psiquiatr, 2018, 47(4): 237-243.
[5] Kitagawa K, Oku N, Kimura Y, et al. Relationship between cerebral blood flow and later cognitive decline in hypertensive patients with cerebral small vessel disease[J]. Hypertens Res, 2009, 32(9): 816-820.
[6] 谢孟桥, 黄惠英, 熊毅, 等. 脑白质疏松患者大脑中动脉血流动力学参数与影像学评分的相关性分析[J]. 中国现代医生, 2017, 55(9): 128-130. XIE Mengjiao, HUANG Huiying, XIONG Yi, et al. Correlative analysis of middle cerebral artery hemodynamics parameters and imaging score in patients with leukoaraiosis[J]. Modern Medicine Journal of China, 2017, 55(9): 128-130.
[7] 丁蓓, 张泳, 黄娟, 等. 遗忘型轻度认知障碍患者脑血流灌注与认知功能的回归分析[J]. 放射学实践, 2016, 31(7): 595-598. DING Bei, ZHANG Yong, HUANG Juan, et al. Regression analysis of cerebral blood perfusion and cognitive function in patients with amnestic mild cognitive impairment[J]. Radiologic Practice, 2016, 31(7): 595-598.
[8] Momtaz YA, Hamid TA, Haron SA, et al. Prevalence of hypotension and its association with cognitive function among older adults[J]. Aging Ment Health, 2018, 22(4): 447-452.
[9] Ghorbani A, Ahmadi MJ, Shemshaki H. The value of transcranial Doppler derived pulsatility index for diagnosing cerebral small-vessel disease[J]. Adv Biomed Res, 2015, 4(1): 54.
[10] Chen YF, Tseng YL, Lan MY, et al. The relationship of leukoaraiosis and the clinical severity of vascular Parkinsonism[J]. J Neurol Sci, 2014, 346(1-2): 255-259.
[11] 王立侠. 不同类型脑小血管病伴发血管性认知功能损害的研究[J]. 中国老年保健医学, 2014, 12(6): 36-38. WANG Lixia. Study on different types of cerebral microvascular disease with vascular cognitive impairment[J]. Chinese Journal of Geriatric Care, 2014, 12(6): 36-38.
[12] Calderón-Garcidueñas L, Mukherjee PS, Kulesza RJ, et al. Mild cognitive impairment and dementia involving multiple cognitive domains in Mexican urbanites[J]. J Alzheimers Dis, 2019, 68(3): 1113-1123.
[13] 黄惠英, 李晓霞, 佐小丽, 等. 脑白质疏松患者认知功能障碍发生特征及危险因素分析[J]. 解放军预防医学杂志, 2017, 35(8): 992-994. HUANG Huiying, LI Xiaoxia, ZUO Xiaoli, et al. Characteristics and risk factors of cognitive dysfunction in patients with leukoaraiosis[J]. Journal of Preventive Medicine of Chinese Peoples Liberation Army, 2017, 35(8): 992-994.
[14] Smith EE, Beaudin AE. New insights into cerebral small vessel disease and vascular cognitive impairment from MRI[J]. Curr Opin Neurol, 2018, 31(1): 36-43.
[15] Pike KE, Chong MS, Hume CH, et al. Providing online memory interventions for older Adults: a critical review and recommendations for development[J]. Australian Psychologist, 2018, 53(5): 367-376.
[16] 戴东璟. 脑小血管病的病变分布特征与临床表现的关系[J]. 中国实用神经疾病杂志, 2015, 18(15): 31-32. DAI Dongjing. The relationship between brain lesions and clinical manifestations of small vessel disease[J]. Chinese journal of practical nervous diseases,2015, 18(15): 131-132.
[17] 何欣. 脑白质疏松症伴轻度认知障碍患者的认知障碍特点分析[J]. 航空航天医学杂志, 2016,27(4): 441-443. HE Xin. Analyse of the characteristics cognitive impairment in patients with leukoaraiosis associated mild cognitive impairment[J]. Journal of Aerospace Medicine, 2016 27(4): 441-443.
[18] 葛永利, 王玉敏, 王洪权. 脑小血管病与氧化应激[J]. 中国老年学杂志, 2018, 38(2): 469-473.
[19] Kohara K, Okada Y, Ochi M, et al. Muscle mass decline, arterial stiffness, white matter hyperintensity, and cognitive impairment: Japan Shimanami Health Promoting Program study[J]. J Cachexia Sarcopenia Muscle, 2017, 8(4): 557-566.
[20] Mok V, Ding D, Fu J, et al. Transcranial Doppler ultrasound for screening cerebral small vessel disease: a community study[J]. Stroke, 2012, 43(10): 2791-2793.
[21] 王前友, 王文静, 刘亮, 等. 轻度认知障碍患者的 SPECT 与 TCD 脑血流改变[J]. 安徽医科大学学报, 2013, 48(1): 69-73.
[22] Lin Q, Huang WQ, Ma QL, et al. Incidence and risk factors of leukoaraiosis from 4683 hospitalized patients: a cross-sectional study[J]. Medicine(Baltimore), 2017, 96(39): e7682.
[23] Wiggins ME, Tanner J, Schwab N, et al. Regional leukoaraiosis and cognition in non-demented older adults[J]. Brain Imaging Behav, 2019, 13(5): 1246-1254.
[24] 张禹, 冯园, 郭大志, 等. 脑白质疏松症的基因与蛋白组学研究进展[J]. 中国医药导报, 2017, 14(22): 55-58. ZHANG Yu, FENG Yuan, GUO Dazhi, et al. Process of gene and proteomics research of leukoaraiosis[J]. China Medical Herald, 2017, 14(22): 55-58.
[25] Sudo FK, Amado P, Alves GS, et al. A continuum of executive function deficits in early subcortical vascular cognitive impairment: a systematic review and meta-analysis[J]. Dement Neuropsychol, 2017, 11(4): 371-380.
[26] Kloppenborg RP, Nederkoorn PJ, Grool AM, et al. Cerebral small-vessel disease and progression of brain atrophy: the SMART-MR study[J]. Neurology, 2012, 79(20): 2029-2036.
[27] Dao E, Hsiung GYR, Liu-Ambrose T. The role of exercise in mitigating subcortical ischemic vascular cognitive impairment[J]. J Neurochem, 2018, 144(5): 582-594.
[28] 窦海彤, 和梅, 李欣. 缺血性脑白质病变的神经影像学及病理学研究进展[J]. 神经损伤与功能重建, 2019, 14(10): 519-522. DOU Haitong, HE Mei, LI Xin. Process of neuroimaging and pathology research of ischemic leukoaraiosis[J]. Neural Injury and Functional Reconstruction,2019, 14(10): 519-522.
[1] WANG Moulong, CHEN Yongkun, XING Deguang, QU Liangsuo, WANG Chengwei. A clinical analysis of transcranial Doppler in predicting delayed cerebral ischemia after ruptured aneurysm surgery [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(11): 38-41.
[2] ZHANG Yin-li1, Ji Zhong-guo1, ZHANG Ying-rui2. Relationship between the cognitive function level and cerebral
hemodynamics in patients with leukoaraiosis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(2): 57-.
[3] QU Chuan-qiang1， YAN Chuan-zhu2， CHEN Pei3， WANG Cui-lan3， GUO Hong-zhi2 . Experimental study of matrix metalloproteinases in the
blood-brain barrier mechanism of leukoaraiosis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(10): 23-27.
[4] ZHU Jian-xin,LI Gang,DENG Lin,SHANG Xiao-ying,GENG Feng-yang. [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2006, 44(10): 1045-1047.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd