JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2013, Vol. 51 ›› Issue (2): 99-103.

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Correlation of Trefoil factor 3 expression in gastric carcinoma and precancerous lesions with angiogenesis

WANG Chen-chen1, GU Xiao-meng1, WANG Yan2, HUANG Shan-ying3   

  1. 1. Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan 250012, China；
    2. Department of Pathology, Qilu Hospital of Shandong University, Jinan 250012, China;  3. Key Laboratory of
    Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Health, Jinan 250012, China
  • Received:2012-07-02 Online:2013-02-10 Published:2013-02-10

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Abstract:

Objective   To investigate the expression of TFF3 in gastric carcinoma and precancerous lesions, and explore the correlation in gastric carcinogenesis and angiogenesis. Methods   The expression of TFF3 was detected by  immunohistochemistry in 26 cases of superficial gastritis, 25 cases of intestinal metaplasia, 20 cases of atypical hyperplasia and 66 cases of gastric carcinoma. MVD was detected by immunohistochemistry using anti-CD34 antibody. Results   The expression of TFF3 was lower in gastric carcinoma than in intestinal metaplasia and atypical hyperplasia, with higher expressions than that in superficial gastritis(P<0.01); MVD was higher in gastric carcinoma than other three groups(P<0.01). There was no significant difference of MVD between intestinal metaplasia and atypical hyperplasia(P>0.05), with higher expressions than that in superficial gastritis(P<0.01). The expression of TFF3 was correlated with lymph node metastasis and TNM staging(P<0.05). The expressions of TFF3 and MVD were positively correlated (r=0.672). MVD with positive expression of TFF3 was higher than that with negative expression(P<0.01). Conclusion   TFF3 may play important roles in carcinogenesis , invasion, metastasis and angiogenesis. It can be used as a useful indicator of the early prediction and prognosis of gastric cancinoma.

Key words: Trefoil factor 3; Stomach neoplasms; Angiogenesis; Microvascular density; immunohistochemistry

CLC Number: 

  • R735.2
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