JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2013, Vol. 51 ›› Issue (10): 81-84.

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Expressions of ERCC1 and C-erbB2 in endometrial carcinoma tissue and their impact on the therapeutic effect of integrated Chinese and Western medicine

FENG Wen1, FANG Yu1, YANG Cheng-xi2   

  1. 1. Department of Gynecology; 2. Department of Medical Oncology, the First People′s Hospital of Lianyungang,
    Lianyungang Hospital Affiliated to Xuzhou Medical College, Lianyungang 222002, Jiangsu, China
  • Received:2012-08-30 Online:2013-10-10 Published:2013-10-10

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Abstract:

Objective  To investigate the expressions of nucleotide excision repair cross-complementing gene (ERCC1) and human epidermal growth factor (C-erbB2) in endometrial carcinoma tissue and their impact on the therapeutic effect of chemotherapy combined with liver-soothing kidney-tonifying formula. Methods  Fifty-one patients with endometrial cancer and 20 subjects with normal endometrium were respectively as endometrial carcinoma group and control group. The former was treated with chemotherapy combined with liver-soothing kidney-tonifying formula. The expressions of ERCC1 and C-erbB2 in endometrial tissue of two groups were detected, and the impact of C-erbB2 and ERCC1 expressions on the therapeutic effect of integrated Chinese and Western medicine was analyzed. Results  The positive expressions of C-erbB2 and ERCC1 in endometrial cancer tissue were increased with histological grading increasing. C-erbB2 positive rate at grade G3 was significantly higher than at grades G1 and G2 (P<0.05), and ERCC1 positive rate at grade G3 significantly higher than at grade G1 (P<0.05). Positive expression rates of C-erbB2 and ERCC1 in endometrial cancer group were significantly higher than in control group (P<0.05 or P<0.01). The therapeutic effect of integrated Chinese and Western medicine on patients with positive expressions of C-erbB2 and ERCC1 was significantly lower than that with negative ones (P<0.05). Conclusion  ERCC1 and C-erbB2 expressions are conducive to determining the pathological grading of endometrial carcinoma, and can be used to assess the therapeutic effect.

Key words: Endometrial cancer; Nucleotide excision repair cross-complementing gene; Oncogene human epidermal growth factor; Liver-soothing kidney-tonifying formula

CLC Number: 

  • R737.33
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