Abstract:

Objective   To investigate the change of extracellular (serum) heat shock protein 70 (eHSP70) in the patients with MODS dynamicaly, and to explore the association of eHSP70 expression with inflammatory facors and the relationship with the disease severity, as well as its clinical value of estimating the clinical prognosis. Methods   Eighty patients with MODS were collected from ICU admission and another 80 normal persons were chosen as the control group. The levels of eHSP70 on admission and in the 24 hours after hospitalization were determined by ELISA respectively. Compute the change of eHSP70 within 24 hours and also measure the inflammatory facors. According to the survival conditions after 20 days treatment, the cases were classified as the “survival group” and the “death group” .The changes of eHSP70 were compared in the two groups and analysed by logistic regression analysis. Results   The levels of eHSP70 on admission and in the 24 hours after hospitalization in the MODS patients were significantly higher than those in the control group (P<0.05). Compared with the survival group, the death group of MODS patients showed an evident increased level of eHSP70. eHSP70 had a positive correlation with inflammatory factors. Adopting Logistic regression analysis, APACHEⅡ scores, the number of dysfunctional organs and especially the change of eHSP70 were proved to be independent and reliable risk factors for estimating the prognosis in MODS patients. Conclusion   The levels of eHSP70 on admission and in the 24 hours of after hospitalization as well as the change of eHSP70 within 24 hours are all closely related with the disease severity and have a positive correlation with inflammatory factors. And the change of eHSP70 is an independent predictor for the prognosis in the MODS patients.

Key words: Multiple organ dysfunction syndrome; Serum heat shock protein 70; Chage; Inflammatory factors; Prognosis