JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2013, Vol. 51 ›› Issue (06): 1-4.

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Role of Heme oxygenase-1 on the apoptosis of myocardial cells induced by angiotensin Ⅱ

GU Ying, WANG Ai-hong, QU Fu-chao, CHEN Dong-chang, ZHANG Ke, LU Ke-feng   

  1. Department of cardiology, Provincial Hospital Affiliated to Shandong University， Jinan 250021, China
  • Received:2012-11-28 Online:2013-06-10 Published:2013-06-10

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Abstract:

Objective   To investigate the role of heme oxygenase-1(HO-1) on the apoptosis of myocardial cells induced by angiotensin Ⅱ. Methods   Neonatal Wistar rats’ myocardial cells were cultured and randomly divided into 4 groups: AngⅡ group, HO-1 inhibitor group, HO-1 induction group and the control group. Western blot was used to detect the HO-1 protein expression. Flow cytometry and Hoechst staining were used to detect the cell apoptosis rate. Results   The apoptosis rate of myocardial cell in AngⅡ group was significantly higher compared with the control group (P<0.05). Compared with AngⅡ group, the apoptosis rate of HO-1 inhibitor group significantly decreased(P<0.05), and the HO-1 protein expression significantly increased(P<0.05). But there were no significant changes of the apoptosis rate and HO-1 protein in HO-1 induction group. Conclusion   HO-1could attenuate the myocardial cells apoptosis induced by AngⅡ.

Key words: Heme oxygenase-1; Myocardial cells; Angiotensin Ⅱ; Cellular apoptosis; Heart failure

CLC Number: 

  • R541.6
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