JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2012, Vol. 50 ›› Issue (8): 40-.

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Role of SPINK1 in prostate cancer: advances in experimental and
translational research

HAN Bo1,3, YANG Xiao-qing1, ZHANG Jing2, LIU Wen-jun3, LIU Long3   

  1. 1. Department of Pathology, School of Medicine, Shandong University, Jinan 250012, China;
    2. Department of Pharmacy, Provincial Hospital Affiliated to Shandong University, Jinan, 250021, China；
    3. Department of Pathology, Qilu Hospital of Shandong University, Jinan 250012, China
  • Received:2012-04-18 Online:2012-08-10 Published:2012-08-10

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Abstract:

Altered genes that play a driving role in cancer development can often serve as specific diagnostic markers, criteria of molecular classification and therefore potential therapeutic targets. Serine protease inhibitor Kazal type 1 (SPINK1), also known as the pancreatic secretory trypsin inhibitor (PSTI) or the tumor-associated trypsin inhibitor (TATI), encodes a 56 amino acid secreted peptide, and its normal function is thought to be the inhibition of serine proteases such as trypsin. Recent studies have indicated SPINK1 may act as an autocrine growth factor and promote prostate cancer growth and invasion. The association between SPINK1 expression and adverse prognosis in prostate cancer has been reported. Notably, SPINK1 might be a novel extracellular therapeutic target in a subset of high-grade prostate cancers. Our preliminary data also suggested that overexpression of SPINK1 was significantly correlated with poor prognosis of prostate cancer patients in China. In this review, our group  will summarize the current understanding of SPINK1 in experimental and translational research of prostate cancer. Its potential applications in prognostic validation and therapeutic target selection for prostate cancer will be highlighted.

Key words:  Serine protease inhibitor kazal type 1; Prostate neoplasms; Biomarker; Prognosis; Translational research

CLC Number: 

  • R737.25
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