JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2012, Vol. 50 ›› Issue (7): 10-.

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Correlation between FTO rs9939609 polymorphism and type 2 diabetes mellitus patients with coronary heart disease

CHEN Jing1, GENG Houfa2, SUN Lin2   

  1. 1. School of Medicine, Shandong University, Jinan 250012, China; 2. The First Department of Endocrinology,
    The Hospital Affiliated to Jining Medical College, Jining 272029, Shandong， China
  • Received:2011-11-28 Online:2012-07-10 Published:2012-07-10

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Abstract:

Objective   To study the correlation between the single nucleotide polymorphism of rs9939609 in FTO (fat mass and obesity-related gene) and type 2 diabetes mellitus (T2DM) patients with coronary heart disease (CHD). Methods   Genotyping of FTO rs9939609 polymorphism was performed in 518 T2DM patients including 256 simple T2DM patients, 262 T2DM with CHD patients and 242 normal controls from the Hospital Affiliated to Jining Medical College using an allelic discrimination assay with the TaqManMGB probes. Gene frequencies were calculated and the clinical parameters of the three groups were compared. Results   Genotype frequencies of TT, TA and AA of FTO rs9939609 in these people were 75.92%, 22.37% and 1.71%, respectively. The frequency for carrying the A allele was 12.89%. The frequency of the A allele was significantly higher in both T2DM and T2DM+CHD groups than that in the control group(P＜0.05). The carriers of the A allele had significantly more risk of T2DM+CHD than the carriers of the T allele(OR=1.62, 95%CI: 1.042.35, P＜0.05). Conclusion   The single nucleotide polymorphism of FTO gene rs9939609 is associated with T2DM+CHD. These results indicate that the A allele polymorphism of rs9939609 site in FTO gene may be one of the risk genes for T2DM+CHD.

Key words: Gene, FTO; Single nucleotide polymorphism; Type 2 diabetes mellitus; Coronary heart disease

CLC Number: 

  • R587.1
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