Abstract:

Object   To investigate the therapeutic efficacy and the follow-up prognosis of low-dose adrenocorticotropic hormone for infantile spasms. Methods   The clinical data of IS patients in hospital from January 2008 to December 2010 were collected. Early effects were analyzed by the retrospective analytical method. In order to determine the longterm prognosis, we followed up the long-term seizures, the mental and motor development as well as the changes of EEG. At the same time, the related factors affecting prognosis were analyzed by logistic regression. Results   Factors influencing longterm seizures were correlated with the etiologies, the course of the disease and the therapeutic effect of ACTH(P<0.05), but not correlated with the onset age(P>0.05). The mental and motor development was correlated with the etiologies (P<0.05), but not correlated with the onset age, the course of the disease and the therapeutic effect of ACTH(P>0.05). The normal rate of EEG was 51.9% followed-up for one year and 66.7% followed-up for more than two years. Conclusions   Low-dose ACTH has an obviously early therapeutic efficacy and its long-term clinical seizure,mental and motor prognosis are better.

Key words: Spasms, infantile; Corticotropin; Follow-up studies