Abstract:

Objective   To explore expressions of Livin and Mcm3 in nasal polyps(NP), and to investigate their relationships  with NP′s clinical stages and recurrence rate. Methods   Expressions of Livin and Mcm3 were detected in 40 cases of NP and 6 cases of normal mucosa of the uncinate process by immunohistochemistry and the image analytical system. Results   Positive expression of Livin between NP and normal mucosa was statistically different(P<0.05), while Mcm3 was not(P>0.05) . Co-expression of Livin and Mcm3 showed a positive correlation with both NP different stages and NP recurrence rate. Conclusion   Over-expression of Livin maybe play a more important role in pathogenesis of NP than Mcm3. Livin and Mcm3 may be reference indexes for prejudgement of NP recurrence.

Key words: Nasal polyps； Apoptosis；  Livin；  Minichromosome maintenance protein 3；  Immunohistochemistry