JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2012, Vol. 50 ›› Issue (12): 65-.

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Relations between serum leptin and leptin receptor Gln223Arg
polymorphism with gastro-esophageal reflux disease

MA Xing-bin1, CHE Xiao-wen2, WU Shuo1, JIN Yun-ling3, ZHANG Nan1,
GUO Jian-qiang1, XU Wei-hua1   

  1. 1. Department of Gastroenterology; 2. Department of Respiratory Diseases; 3. Department of Outpatients,
    Second Hospital of Shandong University, Jinan 250033, China
  • Received:2012-04-06 Online:2012-12-10 Published:2012-12-10

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Abstract:

Objective   To investigate the relations between serum leptin and leptin receptor (LEPR) Gln223Arg polymorphism with gastro-esophageal reflux disease(GERD). Methods   62 patients with GERD were selected according to reflux disease questionnaire and gastroscope inspection and divided into the reflux esophagitis (RE) group and nonerosive reflux disease (NERD) group. In addition, 63 healthy subjects were selected as the control group. The serum leptin levels were determined by ELISA, and LEPR Gln223Arg polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphisms assay. Results   The levels of leptin in RE group and NERD group were both significantly higher than in control group (P<0.05); the degree of inflammation in RE group was positively correlated with leptin level. GA+AA genotype and A allele frequency of LEPR gene in RE group and NERD group were significantly higher than those in control group (P<0.05). The leptin in patients with GA+AA genotype was significantly higher than that in patients with GG genotype (P<0.05). Conclusion   The serum leptin and the LEPR Gln223Arg polymorphism are associated with GERD.

Key words: Gastro-esophageal reflux; Leptin; Receptor； Gln223Arg； Polymorphism

CLC Number: 

  • R571
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[2] YAN Xiao-qing, HAO Hong-sheng, YANG Yi-zuo, LV Guo-ping, SUN Li-juan, LU Xiao-heng. Real-time effect of different concentrations of tea on  gastroesophageal reflux [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(6): 119-124.
[3] ZHANG Hao1， ZHOU Ying-zhi2, DIAO Yutao3, LI Hui-qing3, ZHOU Rui-xue4, ZHAO De-li4 , LEI Fu-hua4. Case-control study of influencing factors of esophagitis in a high incidence area of esophageal squamous cell cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(10): 120-124.
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