JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2011, Vol. 49 ›› Issue (9): 53-.

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Changes of the mineral density of the alveolar bone between T1DM and T2DM rats

LIU Mei1， ZHANG Jun2， WANG Xu-xia3   

  1. 1. Department of Stomatology， Qilu Hospital, Shandong University,  Jinan 250012, China； 2. Department of Orthodontics，
    School of Stomatology, Shandong University,  Jinan 250012, China； 3. Department of Maxillofacial Surgery, School of
    Stomatology， Shandong University, Shandong Key Laboratory of Oral Biomedical, Jinan 250012, China
  • Received:2010-12-11 Online:2011-09-10 Published:2011-09-10

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Abstract:

Objective   To compare the changes of the mineral density of the alveolar bone in Type 1 and Type 2 diabetic rats. Methods   Models of diabetic rats were established by peritoneal injection of STZ. Blood glucose, lipid, and serum insulin, indicators of bone metabolism were determined by quantitative radioimmunoassay, enzyme-linked immunosorbent assay, while the bone mineral density of the right alveolar bone was measured by the dual energy X-ray irradiation method.  Results   The changes of the mineral density alveolar bone of the mandible in normal control rats was similar(P>0.05). Osteoporosis did not happen to treated Type 1 diabetic rats(P>0.05), but it happened to untreated Type 2 diabetic and Type 1 diabetic rats(P<0.05). The changes of the mineral density of the alveolar bone of mandible in treated Type 2 diabetic and Type 1 diabetic rats were similar(P>0.05).  Conclusion   The mineral density of the alveolar bone of mandible in untreated Type 2 diabetic rats was higher than that in Type 1 diabetic rats. Good control of blood glucose levels can prevent osteoporosis.

Key words: Type 1 diabetes mellitus； Type 2 diabetes mellitus； Alveolar bone of mandible； Bone mineral density

CLC Number: 

  • R781.4
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