JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2011, Vol. 49 ›› Issue (7): 94-99.

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Microarray-based gene expression profiles related to breast cancer

GUO Ming-ming， YU Zhi-gang， MA Zhong-bing， GAO De-zong， LI Liang， LI Yu-yang， ZHANG Qiang， WANG Feng， WANG Fei， FU Qin-ye   

  1. Department of Breast Surgery， The Second Hospital of Shandong University， Jinan 250033， China
  • Received:2011-03-03 Online:2011-07-10 Published:2011-07-10

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Abstract:

Objective      To screen differently expressed genes between breast cancer tissues and corresponding normal breast tissues from the same patients. Methods      Three pairs of breast cancer tissues and their corresponding normal breast tissues were screened for differently expressed genes by microarray. Then the result of microarray was verified by real-time PCR. Results       There were 427 differently expressed genes between the two kinds of samples, (231 upregulated genes and 196 downregulated genes). Among these genes, 27 were related to cell proliferation (12 up-regulated and 15 down-regulated), 15 were related to cell adhesion (4 up-regulated and 11 down-regulated), and 13 were related to cell apoptosis (6 up-regulated and 7 down-regulated).  Conclusion      mRNA expression profiles in breast cancer tissues and corresponding normal breast tissues are very different, and the differential genes play important roles in cell adhesion, proliferation, and apoptosis.

Key words: Breast neoplasms; Microarray; Differently expressed genes

CLC Number: 

  • R737.9
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