Abstract:

Objective     To investigate whether lipoic acid can protect the myocardium of patients with acute coronary syndrome and explore the mechanism． Methods       63 patients with acute coronary syndrome were randomly divided into two groups： the lipoic acid group and the conventional medicine group. Patients in the lipoic acid group were given 600 mg lipoic acid every day, while patients in the conventional medicine group were given routine drugs. The course of treatment was one week. The activity of ALDH2, concentrations of hs-CRP and 8-iso PGF2a in all patients were examined before, 24 hours and 1 week after the medication. Results     After24-hour treatment，the activity of ALDH2 in the two groups were significantly higher than before(P<0.001), while the concentration of 8-iso PGF2a decreased (P<0.001). The activity of ALDH2 in the lipoic acid group was much higher than in the conventional medicine group(P<0.01), and 8-iso PGF2a in the lipoic acid group was significantly lower than in the conventional medicine group(P<0.05). After 1week, compared to the before-medication data, the activity of ALDH2 in the two groups was significantly higher(P<0.001), and the concentration of 8-iso PGF2a and hs-CRP were lower(P<0.001). The variation of these three parameters in the lipoic acid group was larger than the conventional medicine group. Also, concentration of 8-isoPGF2a after one-week treatment was lower than that at the end of 24-hour treatment. Conclusion       Lipoic acid may increase the activity of antioxidant enzymes and reduce the serum level of oxidative stress and inflammation factors to protect the myocardium of patients with acute coronary syndrome．

Key words: Acute coronary syndrome； Liopic acid； Aldehyde dehydrogenas2； Isoprostanes； C-reactive protein