Abstract:

Objective       To detect left ventricular function in the patients with hypertrophic cardiomyopathy (HCM) before and after the drug administration by the ratios of E velocity measured by Doppler mitral flow and peak myocardial velocity of the early diastolic wave measured by tissue Doppler imaging (TDI). Methods      Left ventricular diastolic function in the patients with HCM was studied using TDI, pulsed Doppler echocardiography and the ratios of E and E′ before and after esmolol administration. Results        Compared with controls, myocardial segments in the patients with HCM showed lower peak velocity of the early diastolic wave (E′), higher peak velocity of the late diastolic wave (A′), lower E′/ A′ ratio, higher E/ E′ and higher ratio of E/ E′>15. After one-year treatment of metoprolol and perindopril administration, the E′/ A′ ratio was elevated, E/ E′ was decreased, while E/ E′ was decreased after 6-month treatment of perindopril administration and was significantly improved after one year. Conclusions      The ratio of E velocity measured by Doppler mitral flow and peak myocardial velocity of early diastolic measured by TDI technique are useful noninvasive modalities for the early recognition of improvement in the left ventricular diastolic dysfunction.

Key words: Tissue Doppler imaging; Echocardiography; Hypetrophic cardiomyopathy; Metoprolol; Ventricular  diastolic  function