Abstract:

Objective      To analyze characteristics of atherosclerotic plaques in coronary heart disease (CHD) patients with diabetic mellitus(DM) by intravascular ultrasound-virtual histology (IVUS-VH) and to discuss their correlations with glycated serum album (GA) and glycated hemoglobin (HbA1c). Methods       In 53 CHD patients with DM and 49 CHD patients, culprit lesions were detected with IVUS-VH to investigate characteristics of atherosclerotic plaques and their relevance with GA and HbA1c. Results      CHD patients with DM presented a significantly higher prevalence of vulnerable plaques than CHD patients (6.7％：14.5％， P< 0.05), with a clear clustering pattern, mainly consisting of fibro-fatty tissues and necrotic core-rich tissues. There were higher levels of fibrous tissues and dense calcium tissues in CHD patients compared with CHD patients with DM. There was a positive relevance of fibro-fatty tissue with GA(r＝0.018，P<0.05), which was much higher than that with HbA1c. Conclusion      As shown by IVUS-VH, the prevalence of vulnerable plaques in CHD patients with DM is much higher than that of CHD patients, coupled with different intra-plaque compositions, which is associated with the GA level．

Key words: Coronary heart disease patients with diabetic mellitus； Intravascular ultrasound-virtual histology；Glycated serum album；Vulnerable plaques