JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2011, Vol. 49 ›› Issue (7): 1-5.

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Relationship between nonalcoholic fatty liver disease and  the -420 C/G single  nucleotide polymorphism of resistin  in type 2 diabetes mellitus patients

ZHANG Ling-yun1，2, ZHAO Jia-jun1, JIN Yong-jun2, LI Jian-zhou2   

  1. 1. Department of Endocrinology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China;
    2. Department of Endocrinology, Affiliated Hospital of Binzhou Medical College, Binzhou 256603, Shangdong, China
  • Received:2010-12-08 Online:2011-07-10 Published:2011-07-10

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Abstract:

Objective     To investigate the relationships between the resistin gene 5， promoter region-420 C/G polymorphism and nonalcoholic fatty liver disease(NAFLD) in type 2 diabetes mellitus(T2DM). Methods     268 T2DM were selected, including 156 NAFLD,112 without fatty liver disease, and 115 controls, to analyze  the resistin 420 C/G polymorphism genotype by polymerase chain reactionrestriction fragment polymorphism. Result     The distribution of single nucleotide polymorphism at the -420 site in the resistin gene in patients with concurrent T2DM and NAFLD was significantly different from the control(P＜0.05) . In T2DM, the GG genotype was more associated with a 2.40-fold increased risk for NAFLD than the CC genotype(P＜0.05) and 2.08-fold increased risk than the CC+CG genotype  (P＜0.05). The GG genotype was a risk factor for the development of NAFLD in T2DM (OR=3.05，95%CI 1.19-7.86， P＜0.05).  Conclusion     The GG genotype of resistin at -420 may increase the risk of NAFLD in T2DM.

Key words: Type 2 diabetes mellitus；  Resistin gene； Single nuclear polymorphism； Nonalcoholic fatty liver disease

CLC Number: 

  • R587.1
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