JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2011, Vol. 49 ›› Issue (5): 115-118.
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ZHANG Hong-wei,WANG Ji-wen
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Abstract:
Objective To study clinical features of febrile seizure and the correlation between the voltagegated sodium channel α 1 subunit(SCN1A) gene and febrile seizure. Methods A study was conducted among 34 infants with febrile seizure. Clinical data including onset age, seizure type, EEG and prognosis were analyzed. Multiplex ligation-dependent probe amplification(MLPA) technique was applied to detect exon deletions or duplications of the SCN1A gene in 34 infants with febrile seizure. Results Among the 34 infants, there were 29 cases of simple febrile seizure,and 5 cases of complex febrile seizure. No exon deletion or duplication of the SCN1A gene was detected in any of the 34 infants. Conclusion Deletions or duplications in the SCN1A gene might not be a susceptible factor for febrile seizure.
Key words: Seizures, febrile; Genes, SCNIA; Multiplex ligation dependent probe amplification
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ZHANG Hong-wei,WANG Ji-wen . Detection of the SCN1A gene in febrile seizure infants by MLPA technique[J].JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(5): 115-118.
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