Abstract:

Objective    To evaluate the effect of atorvastatin combined with amiodarone on preventing paroxysmal atrial fibrillation(PAF) following dual-chamber-pacemaker implantation in the patients with sick sinus syndrome(SSS)．  Methods     Ninety-four SSS patients suffering from PAF after dual-chamber-pacemaker implantation were randomly divided into the treatment group and the control group． While the patients in the control group were given amiodarone only,  those in the treatment group were administrated with additional atorvastatin (20mg/day). After a 12-month followup, PAF times, AF duration and serum level of C-reactive protein(CRP) were observed． Results     PAF times, AF burden，  AHREs recorded by the pacemaker, the effectiveness of AF treatment and serum level of CRP in the treatment group were significantly lower than in the control group(P<0.05).  Conclusions     Atorvastatin combined with amiodarone can effectively inhibit the occurrence of PAF after dual-chamber-pacemaker implantation in patients with SSS． The mechanism may be attributed to the effect of atorvastatin to inhibit Inflammatory reaction．

Key words: Sick sinus syndrome； Atrial fibrillation； Dualchamber pacing； Amiodarone； Atorvastatin