Abstract:

Objective   To evaluate whether coronary perfusion pressure （CPP） during untreated ventricular fibrillation (VF) and the corresponding VF waveform could be used to predict the probability of return of spontaneous circulation (ROSC).  Methods    VF was electrically induced and sustained for 8 minutes followed by 2 minutes of cardiopulmonary resuscitation and defibrillation in 20 pigs. Hemodynamics, VF mean frequency (VFmf) and VF mean amplitude (VFma) during untreated VF were analyzed by a multipurpose polygraph. According to the outcomes, the animals were categorized into the ROSC or the noROSC group. Results    There were 7 animals in ROSC group and 13 in no-ROSC group. Among ROSC animals, hemodynamic variables were better and both VFmf and VFma were higher than those of the no-ROSC animals (P<0.05). CPP, VFmf and VFma during untreated VF could be used to predict the probability of ROSC (area of ROC curve: 0.86, 0.76, and 0.82, respectively). Both VFmf  and VFma showed  positive correlations with CPP (r=0.67, r=0.71, respectively; P<0.01). Conclusions    Both CPP and VF waveform during untreated VF are valuable indicators for ROSC.

Key words: Ventricular fibrillation; Model, animals; Cardiopulmonary resuscitation; Coronary perfusion pressure; Mean frequency; Mean amplitude; Return of spontaneous circulation