JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2011, Vol. 49 ›› Issue (2): 14-18.

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Expressions of NMDA receptor subunits NR2B and NR2A and their relationship with apoptosis in the hippocampus of Alzheimer′s diseaselike rats

LIU Zhi-an1, 2,  ZHAO Wei-wei3,  L Chun-e2, LI Mei2, XU Tie-jun1, 2   

  1. 1. Jiangsu Province Key Laboratory of Brain Disease Bioinformation, Xuzhou 221002, Jiangsu, China;
    2. Department of Anatomy and Neurobiology, Xuzhou Medical College, Xuzhou 221002, Jiangsu, China;
    3. Department of Radiology, Affiliated Xijing Hospital of The Fourth Military Medical University, Xi′an 710032, China
  • Received:2010-11-02 Online:2011-02-10 Published:2011-02-10

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Abstract:

Objective    To explore expressions of N-methyl-D-aspartate receptor subunits 2B (NR2B) and 2A (NR2A) and their relationship with apoptosis in the hippocampus of Alzheimer′s disease (AD)-like rats. Methods    The AD-like rat model was established by intracerebroventricularly injecting Aβ1-40 and intraperitoneally injecting AlCl3. Expressions of NR2B and NR2A in the AD-like rat hippocampus were detected by immunohistochemistry, and the apoptosis in the AD-like rat hippocampus was detected by TUNEL staining. Then the relationship was further explored between them. Results    Expression of NR2B was significantly increased in the AD-like rat hippocampus(P﹤0.05), especially in the CA1 subfield. Expression of NR2A had no significant change in the AD-like rat hippocampus(P>0.05). Apoptotic cells were significantly increased in the AD-like rat hippocampus (P﹤0.05), especially in the CA1 subfield, followed by the dentate gyrus and the CA3 subfield. Conclusion    NR2B, not NR2A, has pathological high expression in the AD-like rat hippocampus. This pathological high expression may have a specific relationship with AD-like apoptosis and the selective vulnerable phenomenon of the rat hippocampus.

Key words: Alzheimer disease; Receptors, N-methyl-D-aspartate; Apoptosis; Hippocampus; Rats

CLC Number: 

  • R322.81
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