Abstract:

Objective    To study expressions and roles of eukaryotic translation initiation factor 4E (eIF4E) and matrix metalloproteinase-9 (MMP-9) in lesions of psoriasis vulgaris (PS). Methods    Samples were collected from 40 PS patients and 30 healthy controls under informed consent. Expressions of eIF4E and MMP-9 in the samples were detected with the PV-9000 immunohistochemical method. Results    ① No expression of eIF4E was observed in the normal samples, while weak positive and positive expressions were observed in the lesions of PS. ② MMP-9 was expressed in both samples, and the levels of eIF4E and MMP-9 were significantly higher in the lesions of PS than those in the normal skin tissue(P<0.01).  ③ There was no correlation between expressions of eIF4E and MMP-9 in psoriatic lesions. Conclusion    Both eIF4E and MMP-9 are overexpressed in the lesions of PS, and may contribute to the pathogenesis of psoriasis.

Key words: Psoriasis; Eukaryotic translation initiation factor 4E; Matrix metalloproteinase-9