JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2011, Vol. 49 ›› Issue (11): 5-7.

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Influence of advanced glycation end products on prostacyclin and endothelin-1 secretion from human vascular endothelial cells

ZHAO Bao-ming1， LI Feng-liang2， SONG Xi-ming1   

  1. 1. Department of Endocrinology, People′s Hospital of Anyang City, Anyang 455000, Henan, China;
    2. Department of Endocrinology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, Henan, China
  • Received:2011-05-25 Online:2011-11-10 Published:2011-11-10

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Abstract:

Objective   To investigate the influence of advanced glycation end products(AGES) on prostacyclin(PGI2) and endothelin-1(ET-1) secretion from human umbilical vein endothelial cells(HUVEC), and the effect of α-lipoic acid(α-LPA) on it. Methods   HUVEC were obtained by enzyme digestion and primary culture, and divided into the normal control group, the AGES group, the normal+AGES group, and the AGES+α-LPA group. PGI2 and ET-1 in culture media were assayed by radioimmunoassay(RIA) when HUVEC were cultured for 24,48 and 72 hours. Results   ①The content of PGI2 in the AGES group was lower than that in the normal control group（P＜0.05）, while the content of ET-1 was higher（P＜0.05）. ②The content of PGI2 in the AGES+α-LPA group was higher than that in the AGES group （P＜0.05）, while the content of ET-1 was lower（P＜0.01）. Conclusion   AGES can injure vascular endothelial cells, while α-LPA can diminish the injury, which indicates that antioxidants can protect vascular endothelial cells.

Key words: Vascular endothelial cells；  Prostacyclin； Advanced glycation end products;   Endothelin-1； α-lipoic acid

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