Abstract:

Objective    To investigate the serum visfatin levels and explore the relationship between visfatin and other factors， including age， gestational weeks，body mass index，glucose， insulin sensitivity index，insulin secretion index and lipid profile in gestational diabetes mellitus. MethodsThirty-five patients with gestational diabetes mellitus（GDM）and forty-five healthy controls were enrolled . Visfatin levels， as well as lipids， glucose， insulin and HOMA-IR indexes，were measured. Results    Serum visfatin level was elevated in patients with gestational diabetes mellitus compared with the controls. Serum visfatin level was positively correlated with postprandial plasma glucose， fasting insulin and homoeostasis model assessment-insulin resistance. Multiple regression analysis showed that postprandial plasma glucose was an independent related factor influencing serum visfatin level. Conclusion    The increased serum visfatin in gestational diabetes mellitus implies a compensatory mechanism to hyperglycaemia and insulin resistance.

Key words: Visfatin;  Insulin resistance； Gestational diabetes mellitus