Abstract:

Objective  To determine the effect of pulmonary perfusion with HTK solution on lung function during cardiopulmonary bypass (CPB) . Methods  Fourty congenital heart disease patients with pulmonary hypertension were randomly divided into two groups. During CPB, the study group were perfused with 4℃ HTK solution while the control group were not.  IL-6, MDA,RI  and OI were measured at different time points.  Results  The plasma levels of IL-6 and MDA in the study group were lower than those in the control group, and the difference was significant (P＜0.05）.  At each measuring point, OI of the study group was significantly higher than that of the control group (P<0.05).  RI of the study group was significantly lower than that of the control group (P<0.05)  after CPB. Conclusion  This study demonstrated that pulmonary artery perfusion with HTK solution can obviously reduce lung injury after cardiopulmonary bypass.

Key words: Cardiopulmonary bypass； Pulmonary artery perfusion； HTK solution； Lung  protection