Abstract:

Objective  To investigate expressions of matrix metalloproteinase-2（MMP-2） and CXC chemokine receptor 4(CXCR4) in renal clear cell carcinoma（RCCC） tissues and their relationship with clinicopathological characteristics. Methods  Expressions of MMP-2 and CXCR4 in 79 specimens of renal clear cell carcinoma tissues and 43 specimens of normal renal tissues were detected by immunohistochemical PV-6000 technique. Results  The positive rates of MMP-2 and CXCR4 in renal clear cell carcinoma tissues were significantly different from those in normal renal tissues（χ2=36.520，45.009，P<0.01）. Furthermore, expressions of MMP-2 and CXCR4 in renal clear cell carcinoma tissues had  significant relationship with clinical stages of tumor and lymph node metastasis(χ2=3.978-5.657, P<0.05) while not with gender and age of patients and differentiation of cancer (χ2=0.000-2.321, P>0.05). The positive expression of MMP2 was positively related to  that of CXCR4 in renal clear cell carcinoma (r=0.561, P<0.01). Conclusions  Expressions of MMP-2 and CXCR4 in renal clear cell carcinoma tissues are significantly related to genesis, development, metastasis and clinicopathologic parameters of tumor, and maybe play an important role in the progression of renal clear cell carcinoma.

Key words: Renal clear cell carcinoma; Matrix metalloproteinase-2; CXC chemokine receptor 4; Neoplasm metastasis