JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2010, Vol. 48 ›› Issue (6): 100-103.

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Detection and significance of Th17 and Treg cells in patients with chronic heart failure

LI Na, BIAN Hongjun, ZHANG Juan, JI Xiaoping   

  1. Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of
    Public Health, Department of Cardiology, Qilu Hospital of Shandong University, Jinan 250012, China
  • Received:2010-01-02 Online:2010-06-16 Published:2010-06-16

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Abstract:

Objective  To investigate the change of Th17 cells and CD4+CD25+Foxp3+ regulatory T cells (Treg) in patients with chronic heart failure (CHF). Methods   The frequencies of Th17 cells and Treg cells were detected in 49 patients with CHF and 18 healthy controls by flow cytometry. And the 49 patients were divided into 2 groups according to NYHA heart function class: CHF1 group (NYHAⅠ-Ⅱ, n=21) and CHF2 group (NYHAⅢ-Ⅳ, n=28). Results  The frequencies of Th17 cells were significantly higher in patients with poor heart function (CHF1 group and CHF2 group) than in those of normal heart function (the healthy controls) (P<0.01), and the frequencies in CHF2 group were significantly higher than  in CHF1 group (P<0.01). But the change of Treg cells was totally opposite. The frequencies of Treg cells were significantly lower in CHF1 group and CHF2 group than in the healthy controls (P<0.01), the frequencies in CHF2 group were significantly lower than in CHF1 group (P<0.05), and we confirmed that the ratios of Th17/Treg increased with decrease of  the heart function (P<0.01). Conclusion  Th17/Treg imbalance existed in patients with CHF, so it may play a potential role in the onset and development of CHF.

Key words: Heart failure; Th17 cells; CD4+CD25+Foxp3+T cells

CLC Number: 

  • R541.6
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