Abstract:

Objective    To investigate the changes of coagulant and hemostatic parameters in patients with recurrent aphthous ulcer (RAU).  Methods     58 patients with RAU and 50 healthy controls were recruited into the study. RAU patients were classified into three groups: the minor aphthous ulcers (MiAU) group, the major aphthous ulcers (MjAU) group and the herpetiform ulcers (HU) group. Factor VⅢ clotting activity (FVⅢ:C), protein C antigen (PC:Ag), total protein S antigen (TPS:Ag), tissue-type plasminogen activator antigen (tPA:Ag), plasminogen activator inhibitor-1 antigen (PAI-1:Ag) and D-dimer were detected by ELISA or by ACL-200 full automatic coagulation analyzer. Results     PC:Ag, TPS:Ag, PAI-1:Ag and D-Dimer content were significantly higher in RAU patients than in controls (P＜0.01). The level of t-PA:Ag was significantly decreased in patients with RAU (P＜0.01). PC:Ag was lower in the MjAU group than in the MiAU group (P＜0.05). The lever of FVⅢ:C was significantly increased in MiAU patients compared with the controls (P＜0.01), while no statistical significance was observed between MjAU patients and controls (P＞0.05). Conclusion     There were coagulant, anticoagulant and fibrinolytic abnormalities in patients with RAU, and the changes of FVⅢ:C and PC:Ag were correlated with the severity of RAU.

Key words: Recurrent aphthous ulcer; Coagulation; Anticoagulation; Fibrinolysis