Abstract:

Objective      To explore the diagnostic values and relationships of platelet, coagulation, fibrinolytic function and velocity of blood stream in the lower limb deep veins in the state of prethrombosis of benign prostatic hyperplasia (BPH) patients with plasmakinetic resection of the prostate (PKRP) ．Methods      50 BPH patients undergoing PKRP (PKRP group) and 50 non-operative patients (Control group) were enrolled in the study. The plasma platelet (Plt) counting, platelet aggregation index (PAg), platelet adhesion index(PAd), Von Willebrand factor(vWF), prothrombin fragment 1+2 (F1+2), thrombin-antithrombin complex (TAT), fibrogen(Fbg), antithrombin-III  (AT-III), protein C (PC), tissuetype plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), and D-Dimer (DD) were measured by automatic blood viscosity dynamic analyser, ELISA or colorimetric methods. Meanwhile, velocity of blood stream in the lower limb deep veins, popliteal vein (Vpop) and femoral vein (Vfem) were measured by color doppler ultrasound．Results      In PKRP group, the Pag, Pad, vWF, F1+2, TAT, D-D were significantly higher, while ATⅢ and PC were reduced.  Plt, Fbg and PAI-1 were decreased at the beginning but increased later, while the trend of t-PA was just the opposite after the operation. Statistical significances were found(P<0.05)． There was a significant decrease of Vpop and Vfem after the operation compared with those before the operation and the control group (P<0.05). Conclusions     Because that Plt aggregation/ adhesion, coagulation system get strengthened,  anticoagulation/fibrinolytic system get weakened, and velocity of blood stream in the lower limb deep veins get slowed down,prethrombosis is considrable in the BPH patients with PKRP．

Key words: Prostatic hyperplasia; Plasmakinetic resection of the prostate;  Peri-operative period; Thrombopilia