Abstract:

Objective  To explore the effect of PGE2 on damage of intestinal mucosa in obstructed jaundice rats.  Methods A total of 50 Wistar rats were randomly divided into the obstructive jaundice group (A group, n=10), the obstructive jaundice recanalization group (B group, n=10), the obstructive jaundice PGE2 intervention group (C group, n=10), the obstructive jaundice recanalization and PGE2 intervention group (D group, n=10) and the shamoperation group (E group, n=10). Obstructive jaundice models were established by direct ligation. The re-canalization group was  used reperfusion catheterization. PGE2 was used one week after ligation, and materials were drawn at 1 week after reperfusion for observation of morphological changes in the rat small intestine.  Results Scores in small intestinal injury of the PGE2 intervention group (2.21±0.75) and scores in small intestine injury of the recanalization group (2.05±0.71), were less than  the obstructive jaundice group (5.26±0.57, P＜0.05).  Conclusion Small intestinal mucosa of obstructive jaundice rats was markedly impaired. PGE2 and surgical re-canalization may reduce the injury but they have no synergic effect.

Key words: Obstructed, jaundice; Prostaglandin; Intestine; Rats, Wistar