Abstract:

To investigate the state of platelet activation and its influencing factors in subjects with impaired glucose tolerance(IGT). Methods33 patients with IGT were enrolled in this study. 30 DM and healthy persons served as the controls. Percentage and mean fluorescence intensity of CD62P, PAC1 as indexes of platelet activation were measured using whole blood flow cytometry (FCM). Changes of count of blood platelet, mean platelet volume(MPV), platelet distribution width (PDW) and plateletlarge cell ratio(PLCR)were analyzed with a blood cell counter. TC, TG, HDLC, LDLC, VLDLC, FPG and FIns were simultaneously measured. ResultsIGT and subjects with diabetes had higher levels of CD62P%(P＜0.01) and CD62MFI(P＜0.05) and PAC1% (P＜0.01) compared with the NC group. CD62P%,CD62MFI and PAC1% had no statistical differences between the IGT and DM groups(P＞0.05). By stepwise regression analysis, CD62P in the IGT group had relation to PLCR, LDLC, TC and body mass index (BMI) independently. PLCR, MPV and DBP were contributors to PAC1. ConclusionThere is the  same degree of platelet activation in subjects with IGT, and DM. LDLC, TC, DBP and BMI are contributors to CD62P and PAC1 expressions on platelet in IGT.

Key words: Impaired glucose tolerance; CD62P; Platelet activated complex1; Flow cytometry