Abstract:

To investigate the difference of visfatin mRNA expression  in abdominal subcutaneous and omental adipose tissues of  type 2 diabetes and impaired glucose tolerance(the IGT group) and to explore the relationship between visfatin mRNA expression and indexes of correlation metabolism. MethodsThe subjects were Chinese Han population, including 23 controls with no family history of diabetes(the control group), 18 patients with impaired glucose tolerance(the IGT group) and 22 with type 2 diabetes(T2DM group).  The blood pressure, FBG, TC, TG, HDLC, LDLC, HbA1c, and Fins were determined, and (T2DM BMI, WHR, and HOMAIR were calculated. Semiquantitative RTPCR was used to determine  visfatin mRNA expression in adipose tissues. ResultsVisfatin mRNA expression of omental adipose tissues in the T2DM group was higher than that in the IGT and control groups(P＜0.01), but was not significantly different between the IGI group and the control group (P＞0.05). There was no statistical difference in visfatin mRNA expression of subcutaneous adipose tissues among the three groups (P＞0.05). Visfatin expression of omental adipose tissues in the fat/overweight group was higher than that in the control group (P＜0.01). Visfatin mRNA expression of omental adipose tissues was higher than that of subcutaneous adipose tissues (P＜0.01). Correlated analysis showed that visfatin expression of omental a adipose  tissues had a relation to WHR(P＜0.05), but not to  age, BMI,　SBP,　DBP,　FINS,　FBG,　HbA1C, and HOMAIR. While visfatin mRNA expression of subcutaneous adipose tissues was related to TC(P＜0.05). ConclusionVisfatin expression increases in both T2DM patients and fat people, mainly in the omental adipose tissues, and plays effects in maintaining the balance of glucose homeostasis.

Key words: Visfatin, gene; Adipose tissue; Diabetes; Impared glucose tolerance; Obetes